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Structured Review

Human Protein Atlas trpv1 receptor
CBD interacts with the endocannabinoid system. CBD interacts with multiple regulators of the endocannabinoid system, including the endocannabinoid receptors CB 1 and CB 2 . Additionally, CBD indirectly interacts with CB 1 via the enzyme FAAH and β-arrestin. CBD also regulates <t>TRPV1</t> via interactions with CB 1 and inhibits 5HT 1A via interactions with CB 2 . Created with BioRender.com
Trpv1 Receptor, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/trpv1 receptor/product/Human Protein Atlas
Average 90 stars, based on 1 article reviews
trpv1 receptor - by Bioz Stars, 2026-03
90/100 stars

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1) Product Images from "Beyond the hype: a comprehensive exploration of CBD’s biological impacts and mechanisms of action"

Article Title: Beyond the hype: a comprehensive exploration of CBD’s biological impacts and mechanisms of action

Journal: Journal of Cannabis Research

doi: 10.1186/s42238-025-00274-y

CBD interacts with the endocannabinoid system. CBD interacts with multiple regulators of the endocannabinoid system, including the endocannabinoid receptors CB 1 and CB 2 . Additionally, CBD indirectly interacts with CB 1 via the enzyme FAAH and β-arrestin. CBD also regulates TRPV1 via interactions with CB 1 and inhibits 5HT 1A via interactions with CB 2 . Created with BioRender.com
Figure Legend Snippet: CBD interacts with the endocannabinoid system. CBD interacts with multiple regulators of the endocannabinoid system, including the endocannabinoid receptors CB 1 and CB 2 . Additionally, CBD indirectly interacts with CB 1 via the enzyme FAAH and β-arrestin. CBD also regulates TRPV1 via interactions with CB 1 and inhibits 5HT 1A via interactions with CB 2 . Created with BioRender.com

Techniques Used:

CBD interacts with ion channels and G-protein coupled receptors. CBD interacts with multiple ion channels, including the TRP channels TRPM8, TRPV1, TRPV2, TRPV3, TRPV4, and TRPA1, serotonin receptor 5HT 3A , sodium channels Na V 1.1–1.7, L-type calcium channels, voltage-gated potassium channels K V 7.2, K V 7.3, K V 4.3, and K V 11.1, and glycine receptors. CBD interacts with the G protein-coupled receptors GPR3, GPR6, GPR12, and GPR55, the μ-opioid and ∂-opioid receptors, and interacts with receptors who couple with G protein coupled receptors for downstream signaling cascades, including 5HT 1A serotonin receptors and D2 dopamine receptors. Created with BioRender.com
Figure Legend Snippet: CBD interacts with ion channels and G-protein coupled receptors. CBD interacts with multiple ion channels, including the TRP channels TRPM8, TRPV1, TRPV2, TRPV3, TRPV4, and TRPA1, serotonin receptor 5HT 3A , sodium channels Na V 1.1–1.7, L-type calcium channels, voltage-gated potassium channels K V 7.2, K V 7.3, K V 4.3, and K V 11.1, and glycine receptors. CBD interacts with the G protein-coupled receptors GPR3, GPR6, GPR12, and GPR55, the μ-opioid and ∂-opioid receptors, and interacts with receptors who couple with G protein coupled receptors for downstream signaling cascades, including 5HT 1A serotonin receptors and D2 dopamine receptors. Created with BioRender.com

Techniques Used:

CBD interacts with regulators of energy homeostasis. CBD impacts regulators of energy homeostasis, including agonizing PPARγ, inversely agonizing GPR3 and GPR6, and agonizing and inhibiting TRPV1. Created with BioRender.com
Figure Legend Snippet: CBD interacts with regulators of energy homeostasis. CBD impacts regulators of energy homeostasis, including agonizing PPARγ, inversely agonizing GPR3 and GPR6, and agonizing and inhibiting TRPV1. Created with BioRender.com

Techniques Used:



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CBD interacts with the endocannabinoid system. CBD interacts with multiple regulators of the endocannabinoid system, including the endocannabinoid receptors CB 1 and CB 2 . Additionally, CBD indirectly interacts with CB 1 via the enzyme FAAH and β-arrestin. CBD also regulates TRPV1 via interactions with CB 1 and inhibits 5HT 1A via interactions with CB 2 . Created with BioRender.com

Journal: Journal of Cannabis Research

Article Title: Beyond the hype: a comprehensive exploration of CBD’s biological impacts and mechanisms of action

doi: 10.1186/s42238-025-00274-y

Figure Lengend Snippet: CBD interacts with the endocannabinoid system. CBD interacts with multiple regulators of the endocannabinoid system, including the endocannabinoid receptors CB 1 and CB 2 . Additionally, CBD indirectly interacts with CB 1 via the enzyme FAAH and β-arrestin. CBD also regulates TRPV1 via interactions with CB 1 and inhibits 5HT 1A via interactions with CB 2 . Created with BioRender.com

Article Snippet: Because TRPV1 is responsive to high heat (Samanta et al. ), and because it is expressed in the area postrema of the medulla, along gastric enteric and vagal nerves, and on cutaneous receptors in the dermis and epidermis (Tissue expression of TRPV1 - Summary - The Human Protein Atlas ), researchers postulate that repetitive TRPV1 activation may cause vomiting from overexcitation, or relief from the vomiting under acute activation of the hot shower.

Techniques:

CBD interacts with ion channels and G-protein coupled receptors. CBD interacts with multiple ion channels, including the TRP channels TRPM8, TRPV1, TRPV2, TRPV3, TRPV4, and TRPA1, serotonin receptor 5HT 3A , sodium channels Na V 1.1–1.7, L-type calcium channels, voltage-gated potassium channels K V 7.2, K V 7.3, K V 4.3, and K V 11.1, and glycine receptors. CBD interacts with the G protein-coupled receptors GPR3, GPR6, GPR12, and GPR55, the μ-opioid and ∂-opioid receptors, and interacts with receptors who couple with G protein coupled receptors for downstream signaling cascades, including 5HT 1A serotonin receptors and D2 dopamine receptors. Created with BioRender.com

Journal: Journal of Cannabis Research

Article Title: Beyond the hype: a comprehensive exploration of CBD’s biological impacts and mechanisms of action

doi: 10.1186/s42238-025-00274-y

Figure Lengend Snippet: CBD interacts with ion channels and G-protein coupled receptors. CBD interacts with multiple ion channels, including the TRP channels TRPM8, TRPV1, TRPV2, TRPV3, TRPV4, and TRPA1, serotonin receptor 5HT 3A , sodium channels Na V 1.1–1.7, L-type calcium channels, voltage-gated potassium channels K V 7.2, K V 7.3, K V 4.3, and K V 11.1, and glycine receptors. CBD interacts with the G protein-coupled receptors GPR3, GPR6, GPR12, and GPR55, the μ-opioid and ∂-opioid receptors, and interacts with receptors who couple with G protein coupled receptors for downstream signaling cascades, including 5HT 1A serotonin receptors and D2 dopamine receptors. Created with BioRender.com

Article Snippet: Because TRPV1 is responsive to high heat (Samanta et al. ), and because it is expressed in the area postrema of the medulla, along gastric enteric and vagal nerves, and on cutaneous receptors in the dermis and epidermis (Tissue expression of TRPV1 - Summary - The Human Protein Atlas ), researchers postulate that repetitive TRPV1 activation may cause vomiting from overexcitation, or relief from the vomiting under acute activation of the hot shower.

Techniques:

CBD interacts with regulators of energy homeostasis. CBD impacts regulators of energy homeostasis, including agonizing PPARγ, inversely agonizing GPR3 and GPR6, and agonizing and inhibiting TRPV1. Created with BioRender.com

Journal: Journal of Cannabis Research

Article Title: Beyond the hype: a comprehensive exploration of CBD’s biological impacts and mechanisms of action

doi: 10.1186/s42238-025-00274-y

Figure Lengend Snippet: CBD interacts with regulators of energy homeostasis. CBD impacts regulators of energy homeostasis, including agonizing PPARγ, inversely agonizing GPR3 and GPR6, and agonizing and inhibiting TRPV1. Created with BioRender.com

Article Snippet: Because TRPV1 is responsive to high heat (Samanta et al. ), and because it is expressed in the area postrema of the medulla, along gastric enteric and vagal nerves, and on cutaneous receptors in the dermis and epidermis (Tissue expression of TRPV1 - Summary - The Human Protein Atlas ), researchers postulate that repetitive TRPV1 activation may cause vomiting from overexcitation, or relief from the vomiting under acute activation of the hot shower.

Techniques: